张羽

性    别

女

学历学位

研究生学历、农学博士学位

职    称

副研究员

导师类别

硕士生导师

专业领域

动物遗传育种与繁殖

研究方向

卵子成熟与胚胎发育

教育与工作经历

2004年9月-2009年6月，南京农业大学，动物医学专业攻读本科

2009年9月-2011年6月，南京农业大学，临床兽医专业攻读硕士

2011年9月-2014年12月，南京农业大学，临床兽医专业攻读博士

2015年3月-至今，在德赢平台入口任教

联系方式

zhangyu77@njau.edu.cn；

奖励及荣誉

2019 教育部自然科学二等奖（5/5）；2020年，动科院教师教学比赛“二等奖”；2021年，动科院优秀毕业论文指导教师

参加学术团体及任职情况

张羽，博士，副研究员，2014年12月获南京农业大学临床兽医学博士学位，2015年03月至今在德赢平台入口任教。主要开展哺乳动物卵母细胞质量控制与分子调控的机制研究，包括环境内分泌干扰物对卵母细胞成熟质量的影响及卵母细胞内部分子调控机制。首次报道了内分泌干扰物MEHP侵害猪卵母细胞成熟并探索了其保护措施；同时探明了膜泡运输蛋白RAB35和蛋白激酶PKD1调控卵母细胞成熟质量的机制。相关研究在学科权威期刊Molecular  Human Reproduction和Biology of Reproduction上发表，2篇论文当选当期封面文章。

承担科研项目

1.  中央高校基本科研业务费，KYYZ202102, PKD1介导的抗氧化参与藏猪卵母细胞高原低氧适应的机制研究，2021/01/01-2021/12/31，5万元，主持

2.  国家自然科学基金青年基金项目，31601204，Rab35对小鼠卵母细胞成熟过程中极性形成的调控及机制，2017/01-2019/12，22万元，主持。

3.  江苏省自然科学基金青年基金项目，BK20150674，Daam1在猪卵母细胞不均等分裂过程中的功能及机制，2015/07-2018/06，20万元，主持

4.  中国博士后科学基金面上资助，2015M580441，Daam1对猪卵母细胞成熟过程中极性形成的调控及机制，2015/12-2017/11，8万元，主持  

5.  江苏省博士后科研资助计划，1501065B、Rab35对卵母细胞纺锤体迁移和极体排出的功能及机制，2015/08/25-2017/08/24，4万元，主持

6.  南京农业大学专任教师科研启动费，802558，2015/10-2017/10，1万元，主持

7.  中央高校基本科研业务费，KJQN201703，  Rab35对小鼠卵母细胞成熟过程中极性形成的调控及机制，2016/01-2018/12，10万元，主持

8.  博士后国际交流计划学术交流项目，2015，3万元，主持

论文论著：

第一或共同第一作者论文：

1.      Zhang  Y, Wan X, Wang HH, Pan MH, Pan ZN, Sun SC*. RAB35 depletion affects spindle  formation and actin-based spindle migration in mouse oocyte meiosis. Mol Hum  Reprod. 2019, 25(7):359-372.

2.      Zhang  Y, Wu LL, Wan X, Wang HH, Li XH, Pan ZN, Sun SC*. Loss of PKC mu function  induces cytoskeletal defects in mouse oocyte meiosis. J Cell Phyisol. 2019,  234(10):18513-18523.

3.      Zhang  Y, Wang HH, Wan X, Xu Y, Pan MH, Sun SC*. Inhibition of protein kinase D  disrupts spindle formation and actin assembly during porcine oocyte  maturation. Aging. 2018, 10(12):3736-44.

4.      Zhang  Y, Wang T, Lan M, Sun SC*. Melatonin protects oocytes from MEHP  exposure-induced meiosis defects in porcine. Biol Reprod. 2018, 98(3):  286-298.

5.      Zhang  Y, Wang QC, Liu J, Xiong B, Cui XS, Kim NH, Sun SC*. The Small GTPase CDC42  regulates actin dynamics during porcine oocyte maturation. J Reprod Dev.  2017, 63(5): 505-510.

6.      Lu  YJ#; Zhang Y#, Pan MH, Kim NH, Sun SC*, Cui XS*. Daam1 regulates fascin for  actin assembly in mouse oocyte meiosis. Cell Cycle, 2017, 16(14): 1350-1356.

7.      Ma  RJ#, Li HR#, Zhang Y#, Lin Y, Qiu XH, Xie M, Yao B*. The toxic effects and  possible mechanisms of Brusatol on mouse oocytes. PloS One, 2017, 12(5):  e0177844.

8.      Zhang  Y#, Zhu CC#, Sun SC. Cyclin B3: an anaphase onset controller in meiosis. Cell  Cycle, 2015, 14(19): 3013.

9.      Zhang  Y, Wang F, Niu YJ, Liu HL, Rui R, Cui XS, Kim NH, Sun SC*. Formin mDia1, a  downstream molecule of FMNL1, regulates Profilin1 for actin assembly and  spindle organization during mouse oocyte meiosis. BBA Mol Cell Res. 2015,  1853(2): 317-27.

10.    Zhang  Y, Duan X, Cao R, Liu HL, Cui XS, Kim NH, Rui R, Sun SC*. Small GTPase RhoA  regulates cytoskeleton dynamics during porcine oocyte maturation and early  embryo. Cell Cycle. 2014, 13(21): 3390-403.

11.    Zhang  Y, Liu J, Peng X, Zhu CC, Han J, Luo J, Rui R*. KIF20A Regulates Porcine  Oocyte Maturation and Early Embryo Development. PLoS One. 2014, 9(7):  e102898.

12.    Zhang  Y, Wang QC, Han J, Cao R, Cui XS, Kim NH, Rui R, Sun SC*. Involvement of  Dynamin 2 in actin-based polar body extrusion during porcine oocyte  maturation. Mol Reprod Dev. 2014, 81(8):725-34.

13.    Zhang  Y, Duan X, Xiong B, Cui XS, Kim NH, Rui R, Sun SC*. ROCK inhibitor Y-27632  prevents porcine oocyte maturation. Theriogenology. 2014, 82(1):49-56.

其他论文：

14.    Pan  ZN, Pan MH, Sun MH, Li XH, Zhang Y, Sun SC*. RAB7 GTPase regulates actin  dynamics for DRP1-mediated mitochondria function and spindle migration in  mouse oocyte meiosis. FASEB J. 2020, 34(7): 9615-9627.

15.    Pan  MH, Wan X, Wang HH, Pan ZN, Zhang Y, Sun SC*. FMNL3 regulates FASCIN for  actin-mediated spindle migration and cytokinesis in mouse oocytes. Biol  Reprod. 2020, 102(6): 1203-1212.

16.    Lan  M, Zhang Y, Wan X, Pan MH, Xu Y, Sun SC*. Melatonin ameliorates ochratoxin  A-induced oxidative stress and apoptosis in porcine oocytes. Environ Pollut.  2020. 256:113374.

17.    Wang  QC, Wan X, Jia RX, Xu Y, Liu X, Zhang Y, Sun SC*. Inhibition of N-WASP  affects actin-mediated cytokinesis during porcine oocyte maturation.  Theriogenology. 2020, 144:132-138.

18.    Wang  HH, Zhang Y, Tang F, Pan MH, Wan X, Li XH, Sun SC*. Rab23/Kif17 regulate  meiotic progression in oocytes by modulating tubulin acetylation and actin  dynamics. Development. 2019. 146(3): dev171280.

19.    Pan  ZN, Lu Y, Tang F, Pan MH, Wan X, Lan M, Zhang Y, Sun SC*. RAB8A GTPase  regulates spindle migration and Golgi apparatus distribution via  ROCK-mediated actin assembly in mouse oocyte meiosis. Biol Reprod. 2019,  100(3):711-720.

20.    Duan  X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6  modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte  meiosis. BBA-Mol Cell Res. 2018, 1865(2):455-462. (IF=5.3)

21.    Tang  F, Pan MH, Wan X, Lu Y, Zhang Y, Sun SC*. Kif18a regulates Sirt2-mediated  tubulin acetylation for spindle organization during mouse oocyte meiosis.  Cell Div. 2018, 13:9.

22.    Liu  J, Wang QC, Duan X, Cui XS, Kim NH, Zhang Y, Sun SC*. Profilin 1 plays  feedback role on actin-mediated polar body extrusion in mouse oocytes. Reprod  Fertil Dev. 2018, 30(5):752-58.

23.    Pan  MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC*. FHOD1 regulates  cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell  division. J Cell Physiol. 2018, 233(3):2270-2278.

24.    Duan  X, Zhang Y, Chen KL, Zhang HL, Wu LL, Liu HL, Wang ZB, Sun SC*. The small  GTPase RhoA regulates the LIMK1/2-cofilin pathway to modulate cytoskeletal  dynamics in oocyte meiosis. J Cell Physiol. 2018, 233(8):6088-97.

25.    Tang  F, Pan MH, Lu Y, Wan X, Zhang Y, Sun SC*. Involvement of Kif4a in spindle  formation and chromosome segregation in mouse oocytes. Aging Dis. 2018,  9(4):623-633.

26.    Wan  X, Zhang Y, Lan M, Pan MH, Tang F, Zhang HL, Ou XH*, Sun SC*. Meiotic arrest  and spindle defects are associated with altered KIF11 expression in porcine  oocytes. Environ Mol Mutagen. 2018, 59(9):805-812.

27.    Duan  X, Zhang HL, Pan MH, Zhang Y, Sun SC*. Vesicular transport protein Arf6  modulates cytoskeleton dynamics for polar body extrusion in mouse oocyte  meiosis. BBA-Mol Cell Res. 2017: S0167-4889(17)30315-4.

28.    Han  J, Wang QC, Zhu CC, Liu J, Zhang Y, Cui XS, Kim NH, Sun SC*. Deoxynivalenol  exposure induces autophagy/apoptosis and epigenetic modification changes  during porcine oocyte maturation. Toxicol Appl Pharmacol. 2016, 300:70-76.

29.    Ma  R, Zhang Y, Zhang L, Han J, Rui R*. Sirt1 protects pig oocyte against in  vitro aging. Anim Sci J. 2015, (9): 826-32.

30.    Wang  QC, Liu J, Wang ZB, Zhang Y, Duan X, Cui XS, Kim NH, Sun SC*. Dynamin 2  regulates actin-mediated spindle migration in mouse oocytes. Biol Cell.  2014,106 (6): 193-202 .

31.    Duan  X, Chen KL, Zhang Y, Cui XS, Kim NH, Sun SC*. ROCK inhibition prevents mouse  early embryo development. Histochem Cell Biol. 2014, 142(2): 227-233.

32.    Wang  F, An GY, Zhang Y, Liu HL, Cui XS, Kim NH, Sun SC*. Arp2/3 complex inhibition  prevents meiotic maturation in porcine oocytes. PLoS One. 2014, 9(1): e87700.